Folates, folic acid and preconception care – a review

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Biochemistry of Folates and Folic Acid

Folate metabolism affects ovarian function, implantation, embryogenesis and the entire process of pregnancy. In addition to its well-established effect on the incidence of neural tube defects, associations have been found between reduced folic acid levels and increased homocysteine concentrations on the one hand, and recurrent spontaneous abortions and other complications of pregnancy on the ot...

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Hepatic and serum folates in patients fasting and after oral folic acid.

The hepatic folate in non-anaemic hospital patients was found to correlate poorly with the fasting serum folate. The rise in methylfolate in the systemic circulation following the absorption of folic acid was directly related to the folate content of the liver.

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1. The composition of guinea-pig liver folates and the biochemical route of formation of liver folates from injected tritium-labelled pteroylglutamic acid (folic acid) have been studied. 2. Endogenous folate was measured by microbiological assay with Lactobacillus casei and Streptococcus faecalis, with and without deconjugation of whole liver pteroylpolyglutamates (conjugated folates). Individu...

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Studies on Folic Acid in Infancy. 3. Folates in Breast Fed Infants and Their Mothers.

I N A PREVIOUS publication in this series’ it was shown that folate activity in whole blood was lower in infants than in adults. Although increased demand, dictated by rapid growth, undoubtedly is an important factor in determining blood folate levels in this age group, dietary intake may also be of importance. An indication of the effect of the infant’s diet on its blood folate level was provi...

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ژورنال

عنوان ژورنال: JRSM Open

سال: 2021

ISSN: 2054-2704,2054-2704

DOI: 10.1177/2054270420980875